2017 AAOSH Spring Seminar

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Dr. James G MacKenzie, DO

Assistant Professor in Psychiatry and Behavioral Sciences and Pediatrics
Medical Director of Consultation-Liaison and Emergency Services Department of Child and
Adolescent Psychiatry Clinical interests include the recognition and treatment of delirium in
medically hospitalized patients.
Interests - Child and Adolescent psychiatry; Psychiatry; Psychological issues of patients dealing
with medical illness

Kirsten Berding Harold

Kirsten is a fourth year doctoral student in Nutritional Sciences at the University of Illinois at Urbana-Champaign (UIUC) studying under Dr. Sharon Donovan. Before coming to UIUC she received her BS degree in Dietetics from the University of Memphis, TN. Her dissertation research focuses on the interrelationship between nutrition and the gut microbiome in influencing behavior and symptom severity of children with Autism Spectrum Disorder. She will complete her Dietetic Internship to become a Registered Dietitian in the Fall 2017.

Dr. Stephen H. Sheldon, DO, FAAP
Dr. Sheldon is Professor of Pediatrics, Northwest University School of Medicine and Director, Sleep Medicine Center of the Ann and Robert H. Lurie Children’s Hospital of Chicago. He is very active in the clinical practice of pediatric sleep medicine and has an intense involvement in pediatric sleep medical education and research. Dr. Sheldon graduated from Midwestern University’s Chicago College of Osteopathic Medicine and completed his residency in pediatrics at Rush-Presbyterian-St. Luke’s Medical Center, Chicago. He completed a faculty fellowship in Sleep Medicine at the University of Chicago. Dr. Sheldon has served as a consultant on committees and task forces across a wide range of government, academic and public endeavors. Among them are, The Education Committee of the Ambulatory Pediatrics Association, Chair of the Continuing Medical Education Committee and the Fellowship Training Committee of the American Academy of Sleep Medicine. He has served AASM as a board member and as Secretary/Treasurer as well. He currently serves as Associate Editor, The Journal of Clinical Sleep Medicine, and on the boards of the American Insomnia Association and the American Academy of Pediatrics.

Dr. Sheldon is the author of Pediatric Differential Diagnosis, Pediatric Sleep Medicine, Evaluating Sleep in Infants and Children, Atlas of Sleep Medicine in Infants and Children and Differential Diagnosis in Sleep Medicine. He is currently the Senior Editor of the premier textbook for the medical profession on diagnosing and managing all sleep problems in infants and children, Principles and Practice of Pediatric Sleep Medicine.

Craig B Langman MD
The Isaac A Abt MD Professor of Kidney Diseases
Feinberg School of Medicine, Northwestern University
Head, Kidney Diseases, The Ann and Robert H Lurie Children’s Hospital of Chicago

Description

Several rare diseases may affect the skeleton, other organs and the teeth, including hypophosphatasia, X-linked dominant hypophosphatemic rickets, osteogenesis imperfecta, and FAM20A mutations, among others.  After a review of the differential diagnosis of such disorders, the lecture will focus on hypophosphatasia.

Hypophosphatasia is due to more than 250 identified autosomal recessive, or autosomal dominant inherited mutations in the tissue non-specific alkaline phosphatase gene, and has varying age of onset, severity, and systemic manifestations.  The pathophysiology of hypophosphatasia, its clinical phenotypes, and an approach to enzyme replacement therapy will be reviewed. 

Successful learning will be demonstrated by:

1. Discussing the differential diagnosis of early tooth loss coupled with genetic bone disease
2. Discussing the role that the absence of alkaline phosphatase has in systemic calcium homeostasis, including the teeth
3. Providing a framework where enzyme replacement therapy has a key role in improving outcomes in hypophosphatasia.