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New Trends in PRF Therapy in Implant Dentistry, Periodontology and Facial Esthetics

Periodontal and Biofilm Diseases of the Mouth

Presented by: Nathan E. Estrin, DDS, MSc, & Richard J Miron, DDS, MSc, PhD

Original Publication Date: May 21, 2025

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Course Description:

Platelet concentrates have a long history of use in various fields of medicine as an autologous source of growth factors fabricated utilizing centrifugation of blood under various conditions. Over the past 10 years, platelet-rich fibrin (PRF) has seen a steady increase in utilization for a variety of medical and dental procedures due to its lack of anti-coagulation factors favoring fibrin clot formation and faster wound healing. This talk aims to highlight the recent advancements made with respect to the newest formulations of platelet concentrates, including recent developments in horizontal centrifugation. Thereafter, the Bio-Heat technology will be presented as a way to completely replace collagen membranes in dentistry owing to the ability to extend the working properties of PRF from 2-3 weeks to 4-6 months. Lastly, new clinical applications and uses of PRF will be presented in implant dentistry, periodontology, and facial esthetics (Bio-Fillers using PRF). Lastly, antiseptic solutions commonly employed in dentistry, such as chlorhexidine, have historically been utilized in implant dentistry; however, recently, limited fibroblast proliferation and potential cell apoptosis have been demonstrated. This talk will further focus on the combination approach using PRF with StellaLife oral rinses and vitamin formulations in dentistry, leading to better and more intelligent healing and minimizing complications and risks.

Learning objectives:

By the end of this lecture, participants will be able to:

  1. Optimization of protocols for any centrifugation device
  2. Update on Bio-Heat technology and the ability to extend the working properties of PRF from 2-3 weeks to 4-6 months
  3. New uses of PRF in implant dentistry and Facial Esthetics
  4. Use of homeopathic rinses for better wound healing in regenerative dentistry
  5. The importance of vitamin D and early implant failure is what every clinician should know.

Practical Applications:

  1. Integrate PRF to support faster healing and improved tissue regeneration.
  2. Use PRF with homeopathic rinses and vitamin therapies to reduce inflammation and promote cell health.
  3. Screen for vitamin D deficiencies to help prevent complications and early implant failure.

About the Speakers:

Nathan E. Estrin, DDS, MSc:

Dr. Nathan Estrin is a board-certified periodontist and the founder of Estrin Periodontics, with multiple locations across Florida's Gulf Coast. He earned his D.M.D. from LECOM School of Dental Medicine and completed his specialty training in periodontics at Stony Brook University. Dr. Estrin is renowned for his expertise in regenerative, implant, and laser surgery, having authored over 20 peer-reviewed articles and three book chapters in these fields. He is proficient in advanced techniques, including various PRF protocols and laser therapies, and serves as an educator for PRFedu, training dentists nationwide. Outside of his professional endeavors, Dr. Estrin enjoys spending time with his family, staying active, and exploring the outdoors.

Richard J Miron, DDS, MSc, PhD:

Dr. Richard Miron is currently the lead educator and researcher at Advanced PRF Education and an Adjunct Visiting Faculty at the Department of Periodontology in Bern, Switzerland, where he completed his PhD studies in 2009. He has currently published over 350 peer-reviewed articles and lectures internationally on many topics relating to growth factors, bone biomaterials, and guided bone regeneration. For the past 8 years, Dr. Miron has been recognized by Dentistry Today as being one of the top 100 CE providers in the country and the youngest to ever make the list. He is also the top-ranked researcher on Platelet-Rich Fibrin therapy as per Expertscape's independent review. He has recently been awarded many international prizes in dentistry and is widely considered one of the top contributors to implant dentistry, having won the ITI Andre Schroeder Prize, the IADR Young Investigator of the Year in the field of Implant Dentistry as well as the IADR Socransky Research award in the field of Periodontology (2020). He has written 10 textbooks widely distributed in regenerative dentistry including his best-seller in 2019 titled: “Next Generation Biomaterials for Bone and Periodontal Regeneration”, in 2021 titled: “Understanding Platelet Rich Fibrin” and in 2023 titled: "Modern Implant Dentistry".

Conflicts of Interest: 

Dr. Miron: Miron Research and Development in Dentistry
Dr. Estrin: N/A